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You need to click "Save" button to save configuration changes.

Right, almost nothing today compiles for python < 2.5. You need to use python26-pip (though I don't know where you can get this exact package).

See, that's exactly what I mean - there's no passlib package in existence for EL5. Maybe you could try an alternative way? Install python-pip and run 'python-pip install ajenti'

Because there's no easy way to get Python 2.6 (a very outdated 2.5 is default) and required dependencies on EL5.

This looks like a dependency problem to me, please try pre-installing EL5 passlib:

http://download.logilab.org/RPMs/EL5/x86_64/python26-passlib-1.6.1-logilab.noarch.rpm

It turns out that yum from CentOS 5 cannot check 2048 bit key signatures. As you understand, I can't change repo keys just because of CentOS 5 (unsupported anyway). So please use --nogpgcheck with yum to ignore the signature for now.